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Phenotypic disease network (PDN)
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Phenotypic disease network (PDN) : ウィキペディア英語版
Phenotypic disease network (PDN)

The first phenotypic disease network was constructed by Hidalgo et al. (2009) to help understand the origins of many diseases and the links between them. Hidalgo et al. (2009) defined diseases as specific sets of phenotypes that affect one or several physiological systems, and compiled data on pairwise comorbidity correlations for more than 10,000 diseases reconstructed from over 30 million medical records. Hidalgo et al. (2009) presented their data in the form of a network with diseases as the nodes and comorbidity correlations as the links. Intuitively, the phenotypic disease network (PDN) can be seen as a map of the phenotypic space whose structure can contribute to the understanding of disease progression.
==History==
During the last decade, several papers were published that aim at understanding the origins and interrelatedness of diseases using the analytical tools of network science. Interactions between disease-associated genes, proteins, and gene expressions have been explored.
However, phenotypic information was essentially overlooked, despite the fact that there exist extensive, high-quality data on it in the form of clinical histories, until the seminal paper of Hidalgo et al. (2009) introducing the human phenotypic disease network.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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